P3.02c-010 Resistance Mechanisms to PI3K-mTOR Inhibition in NSCLC
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چکیده
منابع مشابه
Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy
Deregulation of the phosphatidylinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) signaling pathway occurs frequently in a wide range of human cancers and is a major driving force in tumorigenesis. Thus, small molecules targeting this pathway are under active development as anticancer therapeutics. Although small-molecule inhibitors of the PI3K-mTOR pathway have shown promising...
متن کاملRAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition
The outlook for patients with advanced renal cell cancer (RCC) has been improved by targeted agents including inhibitors of the PI3 kinase (PI3K)-AKT-mTOR axis, although treatment resistance is a major problem. Here, we aimed to understand how RCC cells acquire resistance to PI3K-mTOR inhibition. We used the RCC4 cell line to generate a model of in vitro resistance by continuous culture in PI3K...
متن کاملInhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.
The PI3K/mTOR-pathway is the most commonly dysregulated pathway in epithelial cancers and represents an important target for cancer therapeutics. Here, we show that dual inhibition of PI3K/mTOR in ovarian cancer-spheroids leads to death of inner matrix-deprived cells, whereas matrix-attached cells are resistant. This matrix-associated resistance is mediated by drug-induced upregulation of cellu...
متن کاملPI3K/Akt/mTOR and CDK4 combined inhibition enhanced apoptosis of thyroid cancer cell lines
Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and...
متن کاملDual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas Running Title: Dual inhibition of PI3K and mTOR in PEL
PI3K/Akt/mTOR-addicted lymphomas Running Title: Dual inhibition of PI3K and mTOR in PEL Aadra P. Bhatt*, Prasanna M. Bhende*, Sang-Hoon Sin, Debasmita Roy, Dirk P. Dittmer and Blossom Damania^. *A.P.B. and P.M.B. contributed equally to this study. Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 2759...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2016.11.1805